Clinical Research Directory

Inclusion Criteria: * Signed Informed Consent Form * Male or female, ≥18 years old. * Immune-competent individuals. * Presenting NLF contour deficiencies with a WSRS score between 2 (shallow wrinkle) and 4 (deep wrinkle) on both the left and right side of the face. Exclusion Criteria: * Having received a prior facial surgery for NLF correction, and/or received any local therapeutic treatment (e.g., dermal fillers). * Having received in the past 2 weeks any local therapeutic treatment of the face below zygomatic arch. * Pigmentation in NLF or having a history of hypo melanosis. * Susceptibility to keloid formation or hypertrophic scarring. * History of a known allergic reaction (e.g., any subject allergic to lidocaine or amide anesthetics, has a history of allergy to Gram-positive bacterial protein, or known to be allergic to any of the constituents of the product: PLLA, sodium carboxymethyl cellulose, mannitol, or sodium hyaluronate). * History of herpes eruption, or a history of malignant skin disorder, or a history of any other serious disease. * Hemorrhagic disease or receiving anti-coagulant therapy. * Presenting with acute inflammation, infection, or having a history of chronic or recurrent infection potentially affecting the safety or performance of the device or increasing risk for adverse events. * Having received in the past 2 months immunosuppressant or systemic steroid therapy. * Having any disease that may affect wound healing, such as connective tissue disorder or serious malnutrition. * Female who is pregnant and/or lactating * Any other condition that as judged by the investigator may make follow-up or Investigation procedures inappropriate