Clinical Research Directory

Colistin Dosage Prsonalization Approach

Sponsor: Mahmoud I Mostafa

Summary

A few studies have evaluated higher doses or the administration or a loading dose, which is routine in adults, in pediatric patients, and reported improved colistin exposure without an increased risk of nephrotoxicity The main questions it aims to answer are What is the optimal dosing strategies of intravenous colistin for the treatment of multidrug-resistant gram-negative bacterial infections in preterm neonates? What is the incidence of AKI? What is the factors increasing AKI incidence? A single center retrospective and comparative study, cohort study compare low dose 5 mg/kg/day versus 7.5mg/kg/day

Official title: Colistin in Neonatal ICU Patients With Gram Negative Resistant Infection: Dosage Personalization Approach

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