Clinical Research Directory

Inclusion Criteria: ● Age 50 through 85, male or female * Sufficient proficiency in English to understand study purpose and directions * Willing and able to give informed consent * Able to follow protocol and attend visits Exclusion Criteria: * History of myocardial infarction, known coronary or carotid disease, or heart failure * History of stroke, Parkinson's disease, dementia, or other major CNS disorders * History of hepatic disease (e.g. hepatitis, cirrhosis) * Recent/recurring history of severe life-threatening medical conditions (e.g. cancer, except non-melanoma skin cancers) * Active major infectious disease (e.g. pneumonia) * Heavy alcohol use (15 drinks or more per week for men or 8 drinks or more per week for women) or substance use disorder * Current use of any medication typically used to treat hypertension or lower blood pressure (e.g. beta-blockers, ACE inhibitors) * Current use of any medication typically used to prevent the coagulation of blood (e.g. warfarin (Coumadin)) * Chronic NSAID use (\>3 times a week for more than 3 months) * Current use of any medication or supplement typically used as a sedative (e.g. zolpidem (Ambien), benzodiazepines (Valium, Xanax), valerian root) * Dietary supplements for improving nitric-oxide synthesis (e.g. L-arginine, L-citrulline) * Current use of any medication typically used to control hypoglycemia (e.g. biguanides (Metformin)) * Current use of any medication typically used for erectile dysfunction (e.g. sildenafil (Viagra), tadalafil (Cialis)) * Pregnant, nursing, or planning a pregnancy within the next 6 weeks * Open skin rashes and sores that may interfere with the placement of sensors