Clinical Research Directory

Inclusion Criteria: * Informed Consent must be signed by the subject prior to any study intervention. * Adult patients (\> 18 years) with severe symptomatic aortic stenosis eligible and scheduled for elective TAVR and are able to give consentand are able to give consent * Indication for B-blocker therapy with a prior treatment duration of at least 1 month before inclusion. Exclusion Criteria: * Emergency or urgent indication for TAVR. * Hemodynamically unstable patients receiving inotropic medication. * Prior permanent pacemaker implantation. * Existing indication for pacemaker implantation. * Hemodynamic relevant left ventricular outflow tract obstruction. * Prior intolerance of B-blocker medication. * Life expectancy \< 1 year. * Known or suspected non-compliance, drug, or alcohol abuse. * Inability to give consent, or follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant. * Being in a dependent relationship with the trial site * Participation in another study with investigational drug within the 30 days preceding and during the present study. * Previous enrolment into the current study. * Pregnancy or breast feeding women