Clinical Research Directory

Inclusion Criteria: * Aged 18 years or above * New onset of sepsis within 48 hours defined according to the Sepsis-3 criteria. (≥2 SOFA) * Provision of signed and dated informed consent form from participant or surrogate * Ability to take and adhere to oral and enteral medication regimen * Willingness to comply Exclusion Criteria: * Current or recent use of SGLT2 inhibitors (within 12wks prior to randomization) * Impaired renal function * Clinically unstable or in refractory hypotension * History of ketoacidosis * Gastrointestinal surgery or GI absorption / malabsorption disorder * Pregnancy * Known allergic or hypersensitivity reactions to any SGLT2 inhibitors * Treatment with another investigational drug or other interventions within 30 days prior to trial