Clinical Research Directory

Inclusion Criteria: 1. Aged 18-75 years old (inclusive), regardless of gender. 2. Patients with locally advanced or metastatic solid tumors confirmed by histology or cytology,. 3. At least one measurable tumor lesion according to RECIST v1.1. 4. ECOG performance score of 0-1. 5. Life expectancy ≥ 12 weeks. 6. Adequate bone marrow and organ function. 7. Have the ability to informed consent, have signed the IRB / EC approved informed consent and dated, willing and able to comply with the treatment plan to visit the inspection and other procedural requirements. Exclusion Criteria: 1. Patients with active central nervous system ( CNS ) metastases. 2. Spinal cord compression not be cured by surgery or radiotherapy. 3. Subjects with uncontrollable tumor-related pain. 4. Clinically uncontrollable the third space effusion. 5. Anti-tumor treatments such as chemotherapy within 4 weeks prior to the first dose of study drug. 6. Received \> 30Gy chest radiotherapy within 24 weeks prior to the first dose of study drug. 7. Major organ surgery or significant trauma within 4 weeks prior to the first dose of study drug. 8. Concomitant other malignancies ≤ 3 years prior to the first dose of study drug. 9. History of interstitial pneumonitis or imaging at screening suggestive of suspected interstitial pneumonitis or inability to exclude interstitial pneumonitis; or other moderate-to-severe lung disease that severely affects lung function. 10. Serious cardiovascular and cerebrovascular diseases. 11. Patients with clinically significant bleeding symptoms within 3 months prior to the first dose of study drug. 12. History of immunodeficiency, including HIV test positive. 13. Active hepatitis B or hepatitis C infection. 14. History of severe allergic reactions to any component of any study drug to be accepted. 15. Known history of alcohol or drug dependence. 16. Mental disorders or poor compliance ; 17. Pregnant or lactating women.