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RIC (Remote Ischemic Conditioning) in Older Individuals
Sponsor: Duke University
Summary
The purpose of this study is to examine the feasibility and acceptability of a technique called remote ischemic conditioning (RIC) that aims to improve muscle strength, muscle mass, exercise tolerance, resilience (i.e. how well someone responds to a stressor), quality of life, physical activity, and physical function when added to rehabilitative exercise training in individuals over age 65 who have some difficulty with mobility.
Official title: Feasibility and Acceptability of Remote Ischemic Conditioning to Achieve High-Intensity Rehabilitation Effects and Increase Resilience in Older Individuals
Key Details
Gender
All
Age Range
65 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2024-09-30
Completion Date
2026-07
Last Updated
2025-12-16
Healthy Volunteers
No
Conditions
Interventions
Low-intensity resistance exercise training
The intervention protocol will consist of 60 minutes of low-intensity resistance exercise training 3x/week for 6 weeks.
High-Dose Remote ischemic conditioning (RIC)
Treatment dose of RIC- the RIC cuff will be inflated to 20 mmHg over the participant's systolic blood pressure. The treatment dose of RIC will be applied in 4 sets of cycles with inflating the cuff and leaving it pumped for 5 minutes then deflating the cuff for an off period of 5 minutes. Total treatment time will be 35 minutes.
Low-Dose Remote ischemic conditioning (RIC)
This dose will be the control for the study. Low-dose RIC- the RIC cuff will be inflated to 10 mmHg below the participant's diastolic blood pressure. The low-dose RIC will be applied in 4 sets of cycles with inflating the cuff and leaving it pumped for 5 minutes then deflating the cuff for an off period of 5 minutes. Total treatment time will be 35 minutes.
Locations (1)
Duke University
Durham, North Carolina, United States