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Permissive Hypotension After Cardiac Surgery
Sponsor: Massachusetts General Hospital
Summary
The objective of this pilot randomized controlled trial is to demonstrate the feasibility of implementing a pragmatic clinical trial randomizing patients to permissive hypotension versus usual care and to determine the impact of permissive hypotension on vasopressor exposure, ICU length of stay, markers of end organ perfusion, and clinically relevant patient outcomes. The data collected from this pilot study will be used as preliminary data for study design and grant applications for a larger multicenter randomized controlled trial.
Official title: Pilot Study- Permissive Hypotension After Cardiac Surgery
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2024-04-20
Completion Date
2026-10-01
Last Updated
2025-12-05
Healthy Volunteers
No
Conditions
Interventions
Permissive Hypotension
Patients will be randomized in 1:1 fashion to either a) Permissive Hypotension (MAP target \> 60mmHg) or b) Usual Care. The duration of the intervention will extend until the patient no longer needs vasopressors to maintain prespecified MAP.
Locations (1)
Massachusetts General Hospital
Boston, Massachusetts, United States