Clinical Research Directory

Inclusion Criteria: Age from 18 to 65 years (male or female). Patients fulfilling criteria of ARDS as per Berline definition who will be admitted to ICU , intubated and MV more than 48 hours will be included in this study. Fulfillment of Criteria of readiness for ARDS as per Berline definition : 1. an acute onset (\<1 week of a known clinical insult or new or worsening respiratory symptoms), 2. respiratory failure not primarily due to hydrostatic edema, 3. bilateral opacities on a chest radiograph (not fully explained by effusions, lobar or lung collapse, or nodules), and 4. \<300 mmHg of the ratio of arterial partial pressure of oxygen (PaO2) to the fraction of inspired oxygen (FiO2) (PaO2/FiO2) with 5 cm H2O of positive end-expiratory pressure (PEEP) or continuous positive airway pressure. To facilitate the estimation of the ARDS prognosis, the Berline definition classifies the severity of ARDS into 3 categories: mild (200 mmHg \< PaO2/FiO2 \< 300 mmHg), moderate (100 mm Hg \< PaO2/FiO2 \<200 mmHg), and severe (PaO2/FiO2 \< 100 mmHg). Exclusion Criteria: * Non intubated ICU admissions * Non-invasive ventilated patients. * Age less than 18 years or more than 65 years of age * Open chest wall trauma. * Patient requiring Extra Corporal Membrane Oxygenator * Patients with increased intrabdominal pressure interfering with mechanical ventilator parameters measurements