Clinical Research Directory

Inclusion Criteria: * 28 days and \<18 years * Treated for sepsis * Received at least 20 ml/kg fluid bolus in the last 4 hours and clinician decides to continue treating signs of shock * Parental/caregiver consent prior to or after enrolment Exclusion Criteria: * Preterm babies born \<34 weeks gestation that have a corrected age of \<28 days * Received ≥ 40 mL/kg of fluid boluses during the 4 h pre-enrolment * Inotrope infusion commenced pre-enrolment * Lack of access (intraosseous, central venous or peripheral) to administer fluids and/or inotropes after 60min of enrolment * Cardiomyopathy or chronic cardiac failure * Chronic hypertension due to cardiovascular or renal disease, requiring regular antihypertensive treatment * Known chronic renal failure (defined as requiring renal replacement therapy) * Known chronic hepatic failure * Palliative care patient/patient with limitation of treatment (not for inotropes, cardiopulmonary resuscitation, extracorporeal membrane oxygenation, intubation or ventilation) * Cardiopulmonary arrest in the past 2 h requiring cardiopulmonary resuscitation of \>2min duration, or death is deemed to be imminent or inevitable during this admission. * Major bleeding with haemorrhagic shock * Sepsis is not likely to be the cause of shock * Previous enrollment in ANDES-CHILD