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RECRUITING
NCT06481592
PHASE2

A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Endometrial Cancer.

Sponsor: Iovance Biotherapeutics, Inc.

View on ClinicalTrials.gov

Summary

The purpose of this study is to investigate the efficacy and safety of the lifileucel regimen in participants with previously treated endometrial cancer.

Official title: A Phase 2, Multicenter, Open-label Study of Lifileucel (Tumor-infiltrating Lymphocytes [TIL]) in Participants With Previously Treated Advanced Endometrial Cancer.

Key Details

Gender

FEMALE

Age Range

18 Years - 70 Years

Study Type

INTERVENTIONAL

Enrollment

60

Start Date

2024-10-29

Completion Date

2029-11

Last Updated

2025-10-30

Healthy Volunteers

No

Interventions

BIOLOGICAL

Lifileucel

A tumor sample is resected from each patient and cultured ex vivo to expand the population of tumor infiltrating lymphocytes. After lymphodepleting chemotherapy including cyclophosphamide and fludarabine, participant is infused with lifileucel, followed by IL-2.

Locations (12)

Honor Health

Phoenix, Arizona, United States

University of Southern California

Los Angeles, California, United States

Orlando Health

Orlando, Florida, United States

H. Lee Moffitt Cancer Center and Research Institute, Inc.

Tampa, Florida, United States

Augusta University

Augusta, Georgia, United States

UofL Health - Brown Cancer Center

Louisville, Kentucky, United States

Barbara Ann Karmanos Cancer Hospital

Detroit, Michigan, United States

Roswell Park Cancer Institute

Buffalo, New York, United States

University of Oklahoma

Oklahoma City, Oklahoma, United States

Allegheny Health

Pittsburgh, Pennsylvania, United States

Avera Medical Group Oncology

Sioux Falls, South Dakota, United States

MD Anderson Cancer Center - U of Texas

Houston, Texas, United States