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A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Endometrial Cancer.
Sponsor: Iovance Biotherapeutics, Inc.
Summary
The purpose of this study is to investigate the efficacy and safety of the lifileucel regimen in participants with previously treated endometrial cancer.
Official title: A Phase 2, Multicenter, Open-label Study of Lifileucel (Tumor-infiltrating Lymphocytes [TIL]) in Participants With Previously Treated Advanced Endometrial Cancer.
Key Details
Gender
FEMALE
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2024-10-29
Completion Date
2029-11
Last Updated
2025-10-30
Healthy Volunteers
No
Conditions
Interventions
Lifileucel
A tumor sample is resected from each patient and cultured ex vivo to expand the population of tumor infiltrating lymphocytes. After lymphodepleting chemotherapy including cyclophosphamide and fludarabine, participant is infused with lifileucel, followed by IL-2.
Locations (12)
Honor Health
Phoenix, Arizona, United States
University of Southern California
Los Angeles, California, United States
Orlando Health
Orlando, Florida, United States
H. Lee Moffitt Cancer Center and Research Institute, Inc.
Tampa, Florida, United States
Augusta University
Augusta, Georgia, United States
UofL Health - Brown Cancer Center
Louisville, Kentucky, United States
Barbara Ann Karmanos Cancer Hospital
Detroit, Michigan, United States
Roswell Park Cancer Institute
Buffalo, New York, United States
University of Oklahoma
Oklahoma City, Oklahoma, United States
Allegheny Health
Pittsburgh, Pennsylvania, United States
Avera Medical Group Oncology
Sioux Falls, South Dakota, United States
MD Anderson Cancer Center - U of Texas
Houston, Texas, United States