Clinical Research Directory

Inclusion Criteria: * 1-12 years children who were the siblings or children of the indicator varicella cases, or the deskmates/roommates of the indicator varicella cases; * Having close contacts with the indicator varicella cases at least 2 days during the period from 5 days before the onset and 2 days after the onset; * Without varicella vaccination history or having varicella vaccination history (the last dose of varicella was manufacured by Sinovac, with an interval of \>30 days before enrollment) * Subjects/legal guardian can understand and sign the informed consent; * Being able to provide legal proof of identity. Exclusion Criteria: * Without varicella history; * Body temperature ≥37.0℃ on the day of enrollment, or skin rash on the head, torso, and limbs; * Having any confirmed or suspected immunodeficiency disorder, including tumor patients undergoing chemotherapy, human immunodeficiency virus (HIV) infection, continuous use of steroid hormones for more than 30 days (prednisone equivalent ≥2mg/kg days in children), or having other immunosuppressive disorder as determined by the clinician; * The investigators considered that participation in this study was not appropriate for various other reasons.