Clinical Research Directory

Inclusion Criteria: * Age ⩾ 18 years. * Patient with an external ventriculostomy implanted at the Toulouse University Hospital. * Patient suspected of nosocomial meningitis due to a febrile syndrome (in the absence of any other identified infectious site), headache, nausea, lethargy, change in neurological status, meningeal syndrome, epileptic event and cutaneous or subcutaneous inflammation at the ventriculostomy site of insertion. * Patient having expressed oral consent, after free and informed information. * Patient affiliated to a social security scheme. Exclusion Criteria: * Diagnosis of community meningitis. * Proven or suspected meningitis and/or ventriculitis during the previous month. * Diagnosis of nosocomial meningitis made in another medical centre prior to admission. * Short bowel syndrome. * Acute mesenteric ischaemia. * End-stage renal failure (GFR \< 15 ml/min/m2). * Peritoneal dialysis. * Patient participating in another research protocol with an exclusion period still in progress. * Pregnant or breastfeeding woman. * Patient under guardianship or trusteeship, persons placed under the protection of justice