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Pericardiotomy in Cardiac Surgery
Sponsor: Population Health Research Institute
Summary
PRINCE is an international, multicentre, randomized controlled trial of posterior pericardiotomy in patients without a history of atrial fibrillation (AF) or flutter undergoing cardiac surgery.
Official title: Pericardiotomy in Cardiac Surgery Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1400
Start Date
2024-10-21
Completion Date
2031-09-01
Last Updated
2025-07-14
Healthy Volunteers
No
Interventions
Left Posterior Pericardiotomy
The surgeon will perform a left posterior pericardiotomy while the patient is on cardiopulmonary bypass. A soft channel drain will be put into place at an angle directed toward the posterior pericardium. The surgeon will grasp the pericardium and use cautery to make a 4- to 5-cm opening between the left inferior pulmonary vein and the diaphragm. The previously prepared channel drain is cut to the desired length and placed through the pericardiotomy along the diaphragm and into the pleural space.
Locations (4)
Weill Cornell Medicine
New York, New York, United States
Medical University Vienna
Vienna, Vienna, Austria
Hamilton Health Sciences
Hamilton, Ontario, Canada
University of Foggia, Policlinico Foggia
Foggia, Foggia, Italy