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Shunt-dependency After aSAH - Role of Early Hyperglycaemia in CSF and Blood
Sponsor: Isabel Hostettler
Summary
The goal of this study is to confirm the association of early increased glucose levels in cerebro-spinal fluid (CSF) and ventriculo-peritoneal-shunt (VPS)-dependency also evaluating the influence of blood glucose on VPS dependency in patients suffering from an aneurysmal subarachnoid haemorrhage (aSAH). The main questions we aim to answer are: * Is there an association of glucose levels on VPS dependency in patients requiring extra-ventricular-drain (EVD) placement for aSAH? * In addition, if there is, what is the influence the course of glucose levels has on VPS dependency? Glucose levels in CSF and serum will be measured on admission, or in case of CSF, upon EVD placement. Glucose in CSF will then be measured every day until EVD removal together with serum glucose. Follow-up will be conducted in person after 3 and 6 months.
Official title: Shunt-dependency After Aneurysmal Subarachnoid Haemorrhage - the Role of Early Hyperglycaemia in Cerebro-spinal Fluid and Blood
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
160
Start Date
2024-03-26
Completion Date
2028-09
Last Updated
2026-03-18
Healthy Volunteers
No
Interventions
Cerebrospinal Fluid (CSF) Sample
Samples for glucose in CSF will be taken upon EVD/LD placement until EVD/LD removal (within the first 14 days).
Blood Serum Sample
Samples for glucose in blood serum will be completed every day, for the first 14 days.
Locations (3)
Cantonal Hospital Aarau
Aarau, Switzerland
University Hospital Basel
Basel, Switzerland
Cantonal Hospital St Gallen
Sankt Gallen, Switzerland