Clinical Research Directory

Biomarkers Associated With Temporomandibular Disorders in Patients With Rheumatoid Arthritis

Sponsor: Josip Juraj Strossmayer University of Osijek

Summary

The goal of this observational study is to determinate temeporomandibular disorders (TMDs) and levels of biomarkers in 30 rheumatoid arthritis patients and 30 healthy controls. Aims are: * to determine TMDs symptoms in both groups using a validated Reasearch Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) protocol * to determine levels of interleukin-4 (IL-4), interleukin-18 (IL-18) and interferon-gamma (IFN-γ) in saliva and serum in RA patients and control group * to determine levels of biomarkers (Ca, Mg, P, AST,ALT,ALP,GGT,urate) in serum of RA patients and control group * investigate the correlation between cytokines level in saliva and serum * to determine the effect of TMDs on cytokine and biomarker levels Participants will be clinicaly examined by DMD in accordance with the RDC/TMD guidelines to receive both Axis I and Axis II diagnoses. After examination participants would be asked for saliva and blood sample.

Official title: Determinants of Orofacial Pain and Temporomandibular Disorders in People With Rheumatoid Arthritis

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