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Spine Unit Modelling Coupled With hIgh Throughput Analysis (SUIT)
Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Summary
Ageing and inflammation represent two main drivers of DDD, a progressive, chronic condition involving vertebral bone, cartilaginous endplate and intervertebral disc. In vitro investigation of the DDD-associated processes on single compartments of the spine unit or ex vivo animal models fail in recapitulating the complex spine pathophysiology or suffer from inter-species differences. Given these premises, a human organotypic model of the spine unit would represent a suitable tool to investigate the DDD-related pathways and to screen promising treatments such as MSC-based therapies.
Official title: Spine Unit Modelling Coupled With hIgh Throughput Analysis (SUIT): Targeting Degeneration With Cell Secretome
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
OBSERVATIONAL
Enrollment
20
Start Date
2023-06-28
Completion Date
2025-08
Last Updated
2024-07-08
Healthy Volunteers
Yes
Conditions
Interventions
Use of patient-derived biological samples
We will use biological samples that are routinely collected as waste material from patients undergoing surgery or from pregnant women giving birth. Peripheral blood will be also collected from patients to conduct virological screening and isolate peripheral blood mononuclear cells.
Locations (2)
IRCCS Ospedale Galeazzi-Sant'Ambrogio
Milan, MI, Italy
IStituto MEditerraneo per i Trapianti e Terapie ad alta specializzazione
Palermo, Italy