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A 3D Bioprinted Hormone-producing Model for BRCA Mutated Patients After Risk Reducing Surgery: the DISC-OVARY Trial
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Summary
Selecting theca and granulosa cells from removed ovaries of BRCA1/2mut patients undergoing Risk-reducing salpingo-oophorectomy (RRSO) and developing a 3D bioprinted hormone-producing bioprosthetic model. If efficacy and tolerability are confirmed in vivo, this bioprosthetic model might be used to replace hormones' production in BRCA mutated patients undergoing prophylactic surgery.
Key Details
Gender
FEMALE
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
3
Start Date
2024-10-10
Completion Date
2027-06-01
Last Updated
2024-10-23
Healthy Volunteers
No
Conditions
Interventions
Theca and Granulosa Cell Isolation
These patients will receive standard procedure during the risk reducing surgery but their ovaries will be used to extract theca and granulosa cells which will be used for the 3D bioprinted device's realisation.
Locations (1)
Day Hospital Tumori Femminili, Policlinico Universitario Fondazione Agostino Gemelli, IRCCS
Rome, Italy