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Geranylgeraniol Supplementation in Patients With Mevalonate Kinase Deficiency
Sponsor: University Hospital, Motol
Summary
Mevalonate kinase deficiency (HyperIgD syndrome, HIDS) is an inborn error of immunity caused by a block in the mevalonate pathway. The subsequent lack of isoprenoids with antiinflammatory properties might contribute to the autoinflammatory nature of the disease. A pilot study aims to verify the safety and efficacy of the dietary supplement Geranylgeraniol, aiming at a mitigation of isoprenoids deficiency caused by the above-mentioned block in the MVK pathway.
Official title: Geranylgeraniol Supplementation in Patients With Mevalonate Kinase Deficiency, MVK Deficiency (hyperIgD Syndrome)
Key Details
Gender
All
Age Range
12 Years - Any
Study Type
INTERVENTIONAL
Enrollment
6
Start Date
2022-01-25
Completion Date
2025-12-31
Last Updated
2024-07-12
Healthy Volunteers
Yes
Conditions
Interventions
geranylgeraniol
GG Pure (Extendlife Natural Products) containing GG gold®30 Annatto Extract, 500 mg capsule, use for 3 months, once daily
Locations (1)
University Hospital, Motol
Prague, Czechia