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Optimizing Subcutaneous FEntanyl titRation: RApid Achievement of Adequate Exposure When Treating Cancer-Related paIn.
Sponsor: Erasmus Medical Center
Summary
The primary objective is to evaluate the effect of loading boluses when dose incresaing treatment with SC fentanyl in patients with cancer. The primary endpoint of this study is to prove the non-inferiority of fentanyl plasma concentrations 12 hours after dose augmentation compared to 48 hours after dose augmentation within each patient. Patients will be treated with additional loading boluses and plasma-PK samples will be obtained.
Key Details
Gender
All
Age Range
18 Years - 120 Years
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2024-02-23
Completion Date
2025-12-02
Last Updated
2024-07-12
Healthy Volunteers
No
Conditions
Interventions
Fentanyl
Administration of subcutaneously administered fentanyl loading boluses
Locations (1)
Erasmus Medical Center
Rotterdam, South Holland, Netherlands