Clinical Research Directory
Browse clinical research sites, groups, and studies.
The Underlying Mechanisms Regarding the Effect of Glucagon on the Kidneys Will be Investigated in Healthy Males.
Sponsor: Ali Asmar
Summary
The goal of this crossover study is to investigate to what extend glucagon affects the kidneys. The main questions it aims to answer are: Does glucagon regulate kidney function through extraction in the kidney in addition to glomerular filtration? Does glucagon regulate kidney function by increasing renal plasma flow and glomerular filtration rate? Does glucagon regulate kidney function by increasing renal salt excretion?
Official title: Renal Extraction of Glucagon and Renal Effects of Glucagon
Key Details
Gender
MALE
Age Range
20 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2024-02-20
Completion Date
2025-07-31
Last Updated
2024-07-12
Healthy Volunteers
Yes
Conditions
Interventions
Glucagon
Glucagon infusion of 5 ng·kg-1·min-1 from 0-60 minutes and 10 ng·kg-1 ·min-1 from 60-120 minutes.
Placebo
Placebo (0.9% NaCl).
Glucagon and exendin 9-39
Glucagon (infusion of 5 ng·kg-1·min-1 from 0-60 minutes) and glucagon (infusion of 10 ng·kg-1 ·min-1 from 60-120 minutes) + a GLP-1R antagonist, exendin 9-39 (900 pmol·kg-1·min-1 from -30-120 minutes).
Locations (1)
Physiological laboratory, Bispebjerg Hospital, Research Unit, Clinical Physiology / Nuclear Medicine Department
Copenhagen, Denmark