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miRNA in Septic Acute Kidney Injury
Sponsor: University Hospital Ostrava
Summary
Acute kidney injury is a common and serious complication of sepsis and septic shock, which may be associated with a worse outcome of the patient's condition. The exact pathophysiological mechanism of septic acute kidney injury remains a challenge. One of the possible causes appears to be endothelial dysfunction and mitochondrial damage of renal tubular cells. The aim of this study is to identify specific microRNAs associated with these pathophysiological events in sepsis and septic acute kidney injury. And to establish a new potential diagnostic or therapeutic target for the prevention or treatment of septic acute kidney injury.
Official title: Specific miRNA Associated With Endothelial Dysfunction and Mitochondrial Damage in Patients With Septic Acute Kidney Injury
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
220
Start Date
2024-05-02
Completion Date
2027-12-31
Last Updated
2024-07-12
Healthy Volunteers
Not specified
Interventions
Laboratory examination to determine the presence of sepsis
Standard laboratory biochemical methods will be used to determine sepsis diagnosis accord-ing to SEPSIS 3 (1). Blood samples for obtaining serum/plasma of the patients will be taken on the 1st and 4th day of sepsis diagnosis.
Laboratory examination to determine the presence of sepsis and acute kidney injury
Standard laboratory biochemical methods will be used to determine sepsis diagnosis according to SEPSIS 3 and acute kidney injury according to Guidelines Kidney Disease Improving Global Outcomes (KDIGO) 2012 (2). Blood samples for obtaining serum/plasma of the patients will be taken on the 1st and 4th day of sepsis diagnosis.
Laboratory examination to determine miRNA and biochemical parameters
Laboratory examination will be performed to determine miRNA and biochemical parameters.
Locations (2)
University Hospital Ostrava
Ostrava, Moravian-Silesian Region, Czechia
University Hospital Olomouc
Olomouc, Olomouc Region, Czechia