Clinical Research Directory

Inclusion Criteria: \- Adults (≥18) candidates for preventive treatment for migraine; those with a frequency of ≥4 monthly migraine days, and who agree to participate in the clinical trial. Exclusion Criteria: * People diagnosed with migraine who are not candidates for preventive migraine treatment * People diagnosed with chronic migraine (\>15 days of headache per month, of which 8 are monthly migraine days) * Not having a smartphone * Simultaneous participation in another clinical trial * Pregnancy or expected pregnancy during the next 3 months * Lactation * People with migraine who already receive preventive treatment. * People on chronic treatment with opioids or other analgesics or NSAIDs that are not used for the symptomatic treatment of migraine, for example, osteoarthritis. * People who, in the opinion of the clinician, have an absolute contraindication to one of the study drugs or who cannot perform the trial procedures: Hypersensitivity to any of the study drugs / Heart block or severe bradycardia / Concomitant treatment with verapamil or diltiazem / Active cardiovascular pathology (recent heart attack, angina, Raynaud's phenomenon) / Major depression or active treatment with antidepressants (including monoamine oxidase inhibitors and St. John's wort) / Other psychiatric illnesses or active treatment with antipsychotics or lithium / Severe liver disease or kidney failure / Parkinson's disease or other extrapyramidal disorders / Epilepsy (diagnosis and/or active treatment) / Any other contraindication that, in the opinion of the clinician, prevents participation in the clinical trial