Clinical Research Directory
Browse clinical research sites, groups, and studies.
Non-invasive Brain Tumor Molecular Diagnostics and Monitoring
Sponsor: The Institute of Molecular and Translational Medicine, Czech Republic
Summary
This prospective multicenter study aims to enroll GBM patients who will undergo repeated assessments (preoperatively and 3 months post-surgery) to detect circulating tumor cells and analyze the transcriptomic profiles of EVs in their blood. The prognostic and monitoring significance of these biomarkers to disease course (assessing treatment efficacy, resistance incidence, tumor progression) will be evaluated. Concurrently, proteomic profiles typical of GBM will be analyzed in blood and ocular secretion samples from GBM patients, patients with low-grade gliomas, and patients without brain tumors to identify and validate novel protein biomarkers suitable for disease monitoring. Additionally, this study proposes an innovative approach to monitor GBM patients by investigating the presence of GBM-specific nucleic acid fragments in urine.
Official title: Non-invasive Brain Tumor Diagnosis Through Analysis of Proximal Fluids, Circulating Tumor Cells, and Biomolecules
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2020-01-01
Completion Date
2030-12-31
Last Updated
2025-07-18
Healthy Volunteers
Yes
Conditions
Interventions
Diagnostic test
No intervention among the arms. The diagnostic, prognostic, predictive and follow-up value of tested biomolecules will be analyzed.
Locations (1)
Department of Neurosurgery, University Hospital Olomouc
Olomouc, Czechia