Clinical Research Directory

Inclusion Criteria: 1. Age ≥18 years; 2. Weight ≥30 kg; 3. Intra-abdominal infection (blood or abdominal drainage fluid culture positive for Gram-negative bacteria or suspected to be caused by a Gram-negative agent); 4. Diagnostic septic shock (Sepsis 3.0): Sepsis was defined as "life-threatening organ dysfunction caused by a dysregulated host response to infection" with organ dysfunction defined as an increase in qSOFA ⩾2 points. Septic shock was defined as sepsis requiring vasoactive therapy to maintain mean arterial pressure (MAP) ⩾ 65 mmHg and lactate elevation to \>2 mmol/L despite adequate volume resuscitation; 5. The dose of norepinephrine⩾0.4ug/kg/min; 6. PCT⩾50ug/L, and/or IL-6⩾1000pg/ml; 7. AKI stage II/III (Kidney Disease Improving Global Outcomes, KDIGO grade); 8. Duration of septic shock ≤48 hours. Exclusion Criteria: 1. Patients with highly contagious infectious diseases, such as tuberculosis; 2. Pregnant and lying-in woman or lactation period; 3. Infection of other sites (no abdominal infection like pneumonia, central nervous system infection and so on); 4. CRRT cannot be performed for various reasons; 5. Death is expected within 48 hours of admission to the ICU; 6. Previous renal replacement therapy; 7. Patients that underwent cardio-pulmonary resuscitation (CPR); 8. Patients who will not sign the informed consent form.