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Research on Key Technologies for Risk Prediction and Precise Diagnosis and Treatment of AIS Based on Epigene-phenotype
Sponsor: The First Affiliated Hospital of Zhejiang Chinese Medical University
Summary
Mining AIS biomarkers, elucidating the new mechanism of AIS pathogenicity, constructing risk prediction models, optimizing AIS precise diagnosis and treatment techniques, formulating precise diagnosis and treatment protocols and technical specifications for AIS combined with Chinese and Western medicine with independent intellectual property rights, and realizing the full coverage of Zhejiang Province by the end of 2026, so as to form the "Zhejiang experience" of AIS diagnosis and treatment.
Official title: Research on Key Technologies for Risk Prediction and Precise Diagnosis and Treatment of Adolescent Idiopathic Scoliosis Based on Epigene-phenotype
Key Details
Gender
All
Age Range
10 Years - 18 Years
Study Type
INTERVENTIONAL
Enrollment
2000
Start Date
2024-09-01
Completion Date
2026-12-31
Last Updated
2024-07-17
Healthy Volunteers
Yes
Conditions
Interventions
Low risk experimental group
Guiding + Manipulation + Traditional Chinese Medicine
Medium risk experimental group
Guiding + Manipulation + Traditional Chinese Medicine + Specific Exercise Therapy + Orthopedic Braces
High risk experimental group
Guiding + Manipulation + Traditional Chinese Medicine + Specific Exercise Therapy + Orthopedic Braces + Specialized Inpatient Rehabilitation
Control group COBB 10-20°
Specific Exercise Therapy
Control group COBB 20-45°
Orthopedic Braces + Specific Exercise Therapy
Control group COBB >45°
Orthopedic Braces + Specific Exercise Therapy + Recommended Surgery
Experimental group (AIS group)
Molecular marker exploration and validation
Control group (healthy control)
Molecular marker exploration and validation
Controlled follow-up before and after AIS
Construction and validation of AIS risk prediction model completed
Locations (1)
Prokin balance apparatus
Hangzhou, Zhejiang, China