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Impact of Combined Oral Contraceptive Pills on Migraine
Sponsor: Kafrelsheikh University
Summary
The investigators will assess the effect of combined oral contraceptive pills (COCs) on migraine features and treatment response to allow better interpretation of the exact consequence of hormonal contraceptive use on migraineurs.
Official title: Impact of Combined Oral Contraceptive Pills on Migraine, a Randomized Controlled Trial
Key Details
Gender
FEMALE
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2024-07-15
Completion Date
2025-07-30
Last Updated
2024-10-09
Healthy Volunteers
No
Conditions
Interventions
Combined oral contraceptive
The arm will include 200 migraine patients diagnosed according to ICHD3-beta criteria. The patients are regular users of COCs and will receive propranolol 80-160mg daily and ibuprofen 200-400 mg only in acute migraine attacks for 3 months.
Vaginal Ring
The arm will include 200 migraine patients diagnosed according to ICHD3-beta criteria. The patients are users of mechanical contraceptive methods and will receive propranolol 80-160mg daily and ibuprofen 200-400 mg only in acute migraine attacks for 3 months.
Locations (1)
Kafr Elsheikh University Hospital
Kafr ash Shaykh, Egypt