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Sildenafil to Reduce Vascular Remodeling During Left Ventricular Assist Device Support
Sponsor: Montefiore Medical Center
Summary
Contemporary left ventricular assist device (LVAD) therapy improves survival during advanced heart failure but vascular aging develops rapidly leading to major adverse events including stroke and bleeding in nearly half of patients. In this study, the study team aims to investigate whether sildenafil pharmacotherapy, which has anti-fibrotic effects, can reduce vascular aging during LVAD support. An aim of this study is to compare changes in small blood vessels in the gastrointestinal tract between participants receiving sildenafil or placebo. Video capsule endoscopy (VCE) will be used to assess these changes in small blood vessels.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2025-03-12
Completion Date
2029-12
Last Updated
2026-01-23
Healthy Volunteers
No
Conditions
Interventions
Sildenafil
Orally administered phosphodiesterase-5 (PDE-5) inhibitor, which enhances nitric oxide signaling in platelets and blood vessels.
Placebo
Matched capsule not containing any medication
Locations (1)
Montefiore Medical Center
The Bronx, New York, United States