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Vulnerability and Risk of Neuropathic Pain in Cancer
Sponsor: University Hospital, Clermont-Ferrand
Summary
Successive and repeated therapeutic interventions during cancer management - surgery, chemotherapy, radiotherapy - can all, to varying degrees, generate acute pain, central pain sensitization and chronic pain. Almost 58% of patients suffer from chronic pain, often of the neuropathic type, with altered quality of life and disease burden amplified by difficulty in achieving effective relief. Indeed, neuropathic pain in cancer remains difficult to treat, often arrives insidiously, may persist well beyond cancer remission, and frequently has a fate that is difficult to predict. Current treatments for neuropathic pain are based on the recommendations of learned societies, but therapeutic failures are frequent, and iatrogenic pathology is high. Many factors have been identified as being associated with the development of chronic pain in cancer patients. The intensity of preoperative pain, opioid consumption, age, sleep disorders, cognitive-emotional state, psychological vulnerability and social precariousness are all factors that influence and perpetuate chronic pain linked to cancer and its management. Several studies have shown that 6 months or 1 year after cancer diagnosis, there are various pain trajectories, enabling us to identify several pain patient phenotypes. The patient's overall state of vulnerability at the time of cancer diagnosis has an impact on the trajectory of pain chronicisation, and it is often difficult for clinicians to apprehend this risk. In practice, we lack a validated, easy-to-use tool that would enable us to predict the risk of pain chronicisation for each patient, even before the start of the treatment process.
Official title: Vulnerability and Risk of Neuropathic Pain in Cancer: Validation of a Predictive Tool to Optimize Treatment.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
625
Start Date
2024-10-28
Completion Date
2028-06-30
Last Updated
2025-12-08
Healthy Volunteers
Yes
Conditions
Interventions
Cognitive-emotional and pain assessments
Data collection on cognitive-emotional and pain parameters using questionnaires.
Locations (19)
Centre Hospitalier d'Ajaccio
Ajaccio, France
Centre de Lutte contre le Cancer - Institut de Cancérologie de l'Ouest
Angers, France
Centre Hospitalier Henri Mondor d'Aurillac
Aurillac, France
Centre de Lutte contre le Cancer - Institut Bergonié
Bordeaux, France
Centre de Lutte contre le Cancer - Centre François Baclesse
Caen, France
Centre Hospitalier Universitaire Caen Normandie
Caen, France
Centre de Lutte contre le Cancer - Jean Perrin
Clermont-Ferrand, France
CHU de Clermont-Ferrand
Clermont-Ferrand, France
Hôpitaux civils de Colmar
Colmar, France
Centre Régional de Lutte contre le Cancer - Georges Francois Leclerc
Dijon, France
Hôpital privé le Bois
Lille, France
Centre Hospitalier de Montluçon
Montluçon, France
Centre Hospitalier de Moulins-Yzeure
Moulins, France
Hôpital Saint-Louis APHP
Paris, France
Hôpital Beaujon AP-HP
Paris, France
Institut Godinot
Reims, France
Centre Hospitalier Yves Le Foll
Saint-Brieuc, France
CH Valenciennes
Valenciennes, France
Institut Gustave Roussy
Villejuif, France