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RECRUITING
NCT06511674
NA

Vulnerability and Risk of Neuropathic Pain in Cancer

Sponsor: University Hospital, Clermont-Ferrand

View on ClinicalTrials.gov

Summary

Successive and repeated therapeutic interventions during cancer management - surgery, chemotherapy, radiotherapy - can all, to varying degrees, generate acute pain, central pain sensitization and chronic pain. Almost 58% of patients suffer from chronic pain, often of the neuropathic type, with altered quality of life and disease burden amplified by difficulty in achieving effective relief. Indeed, neuropathic pain in cancer remains difficult to treat, often arrives insidiously, may persist well beyond cancer remission, and frequently has a fate that is difficult to predict. Current treatments for neuropathic pain are based on the recommendations of learned societies, but therapeutic failures are frequent, and iatrogenic pathology is high. Many factors have been identified as being associated with the development of chronic pain in cancer patients. The intensity of preoperative pain, opioid consumption, age, sleep disorders, cognitive-emotional state, psychological vulnerability and social precariousness are all factors that influence and perpetuate chronic pain linked to cancer and its management. Several studies have shown that 6 months or 1 year after cancer diagnosis, there are various pain trajectories, enabling us to identify several pain patient phenotypes. The patient's overall state of vulnerability at the time of cancer diagnosis has an impact on the trajectory of pain chronicisation, and it is often difficult for clinicians to apprehend this risk. In practice, we lack a validated, easy-to-use tool that would enable us to predict the risk of pain chronicisation for each patient, even before the start of the treatment process.

Official title: Vulnerability and Risk of Neuropathic Pain in Cancer: Validation of a Predictive Tool to Optimize Treatment.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

625

Start Date

2024-10-28

Completion Date

2028-06-30

Last Updated

2025-12-08

Healthy Volunteers

Yes

Interventions

OTHER

Cognitive-emotional and pain assessments

Data collection on cognitive-emotional and pain parameters using questionnaires.

Locations (19)

Centre Hospitalier d'Ajaccio

Ajaccio, France

Centre de Lutte contre le Cancer - Institut de Cancérologie de l'Ouest

Angers, France

Centre Hospitalier Henri Mondor d'Aurillac

Aurillac, France

Centre de Lutte contre le Cancer - Institut Bergonié

Bordeaux, France

Centre de Lutte contre le Cancer - Centre François Baclesse

Caen, France

Centre Hospitalier Universitaire Caen Normandie

Caen, France

Centre de Lutte contre le Cancer - Jean Perrin

Clermont-Ferrand, France

CHU de Clermont-Ferrand

Clermont-Ferrand, France

Hôpitaux civils de Colmar

Colmar, France

Centre Régional de Lutte contre le Cancer - Georges Francois Leclerc

Dijon, France

Hôpital privé le Bois

Lille, France

Centre Hospitalier de Montluçon

Montluçon, France

Centre Hospitalier de Moulins-Yzeure

Moulins, France

Hôpital Saint-Louis APHP

Paris, France

Hôpital Beaujon AP-HP

Paris, France

Institut Godinot

Reims, France

Centre Hospitalier Yves Le Foll

Saint-Brieuc, France

CH Valenciennes

Valenciennes, France

Institut Gustave Roussy

Villejuif, France