Clinical Research Directory

Inclusion Criteria: 1. All ages, male or female 2. Carriers of the pathogenic genes mutation (mutation with unknown clinical significance/ suspected pathogenic mutation/ pathogenic mutation) of hCSVD confirmed by the gene tests, including but not limited to NOTCH3, HTPA1, CTSA, GLA, TREX1, COL4A1/2, or highly-suspected hCSVD2 3. CSVD related abnormalities on brain MRI, any 1 or more of: 1. White matter hyperintensities, Fazekas score3 ≥1 2. ≥1 newly-occurred lacunar infarcts 3. ≥1 old lacunar infarcts 4. ≥3 cerebral microbleeds 4. Informed consent signed Exclusion Criteria: 1. Diagnosis of mental disorders according to DSM-V and unable to be compliant to the research 2. Patients with life expectancy less than one year due to any advanced disease, e.g., malignant tumor 3. Patients unable to return for follow-up visits due to some reasons