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10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery
Sponsor: Cairo University
Summary
Data regarding the optimum dose of norepinephrine for management of severe maternal hypotension is lacking. A previous report showed that the use of 10-mcg norepinephrine bolus was not superior to the 5-mcg bolus in the management of severe hypotension in addition the incidence of reactive bradycardia and hypertension was comparable in the two doses. Therefore, we hypothesize that using a higher dose of norepinephrine (15 mcg) would increase the success rate of management of severe hypotensive episode.
Official title: Comparing 10- Versus 15-mcg Norepinephrine Bolus for Management of Severe Post-spinal Hypotension During Elective Cesarean Delivery: A Randomized, Controlled Trial
Key Details
Gender
FEMALE
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
184
Start Date
2024-08
Completion Date
2024-12
Last Updated
2024-07-22
Healthy Volunteers
No
Interventions
10 mcg Norepinephrine
The assigned dose (10 mcg) will be diluted with normal saline in a 10-cc syringe
15 mcg Norepinephrine
The assigned dose (15 mcg) will be diluted with normal saline in a 10-cc syringe.
Locations (1)
Cairo University
Cairo, Egypt