Clinical Research Directory

Inclusion Criteria: (1)From February 1, 2023, to March 30, 2024, diagnosed with severe pneumonia in the Respiratory Intensive Care Unit of Xiangya Hospital, Central South University. The diagnosis of severe pneumonia is based on meeting at least one major criterion or three or more minor criteria: 1. Major criteria: ①Infectious shock requiring vasopressor therapy despite adequate fluid resuscitation;②Respiratory failure requiring tracheal intubation or mechanical ventilation. 2. Minor criteria: * Respiratory rate ≥ 30 breaths/min; ②Oxygenation index (PaO2/FiO2) ≤ 250; * Involvement of multiple lobes; ④Altered mental status and/or disorientation; ⑤Blood urea nitrogen ≥ 20 mg/dl (7.14 mmol/L); ⑥Systolic blood pressure \< 90 mmHg requiring aggressive fluid resuscitation. (2)Patients receiving mechanical ventilation who require sedation treatment. (3)Age ≥ 18 years. Exclusion Criteria: 1. Allergic to routine sedative or analgesic medications. 2. Patients who have not undergone pain and sedation assessment. 3. Patients transferred to another hospital during treatment. 4. Patients who abandon treatment and are discharged within less than 72 hours of treatment.