Clinical Research Directory

Inclusion Criteria: (1)From February 1, 2023, to December 31, 2024, diagnosed with severe pneumonia in the Respiratory Intensive Care Unit of Xiangya Hospital, Central South University. The diagnosis of severe pneumonia is based on meeting at least one major criterion or three or more minor criteria: 1. Major criteria: ①Infectious shock requiring vasopressor therapy despite adequate fluid resuscitation; ②Respiratory failure requiring tracheal intubation or mechanical ventilation. 2. Minor criteria: * Respiratory rate ≥ 30 breaths/min; * Oxygenation index (PaO2/FiO2) ≤ 250; ③Involvement of multiple lobes; * Altered mental status and/or disorientation; ⑤Blood urea nitrogen ≥ 20 mg/dl (7.14 mmol/L); ⑥Systolic blood pressure \< 90 mmHg requiring aggressive fluid resuscitation. (2)Patients receiving invasive mechanical ventilation who require continuous sedation treatment. (3)Age ≥ 18 years. Exclusion Criteria: 1. Allergic to routine sedative or analgesic medications. 2. Patients who have not undergone sedation-agitation assessment. 3. Patients transferred to another hospital during treatment. 4. Patients who withdrew from active treatment or were discharged from the ICU within 72 hours after initiation of sedation.