Clinical Research Directory

Inclusion Criteria: * At the time of the study, be a seasonal farm worker at one of the selected farm sites in Metema district * Available and willingness to participate in the study and provide consent (or parental/guardian consent and asset in the case of minors) Exclusion Criteria: * Severe illness (will be referred for care) * Inability to provide informed consent * Age 14-17 years old and not having a parent/guardian at the farm who can provide consent * Age \<14 years old Additional exclusion criteria for the intervention group: * Having received an antimalarial drug within the last 2 weeks * Having any of the contraindications to receiving DP: * History of cardiac rhythm disturbances, bradycardia, or heart failure * Concomitant treatment with drugs that prolong the QT interval (fluconazole, fluoroquinolones, hydroxyzine, macrolides, ondansetron, etc.) or drugs containing any of the following: flecainide, metoprolol, imipramine, amitriptyline, clomipramine * Known allergic reactions to DP or other artemisinin derivatives * Pregnancy