Clinical Research Directory

Inclusion Criteria: * 18-65 years * Phototype II-V * 50% with sensitive skin (declarative); * Subjects should be affected by well defined symmetrical (on both sides of the face) epidermal melasma (clinically diagnosed under Wood's light examination) lasting since more than a year Exclusion Criteria: * Subjects under topical or systemic retinoids; * Subjects having used topical tretinoin within 3 months or topical hydroquinone within 6 months prior to inclusion; * Subjects under systemic immunosuppressants and considered immune compromised * Subjects under active treatment of melasma (including topicals or procedures) within the last 3 months * Pregnant women and/or breastfeeding women * Subjects with a recent change in contraception (since less than 6 months); * Subjects known allergy to any component of tested product; * Subjects not presenting with the conditions needed to comply with the protocol; * Subjects without any other dermatological conditions on the face * Subject under menopause phase with hormonal replace therapy * Subjects in the initial phase, change or discontinuation of hormonal treatment (estroprogesterone, cyproteron acetate, androgenic...) in the last 3 months; * Subjects currently using any medication, which in the opinion of the investigator, may affect the evaluation of the study product, or place the subject at undue risk. * Subjects unable to give their informed consent.