Clinical Research Directory

Inclusion Criteria: 1. Age ≥18 years, male or female. 2. Diagnosis consistent with refractory AA after radiotherapy. refractory is defined as patients who have failed to respond to at least an adequate amount of supportive therapy, cyclosporine or povidone TPO-RA for 3 months . 3. At least one of the following conditions was met at enrolment: haemoglobin \<90 g/L. Platelets \<30 x 10\^9/L, neutrophils \<1.0 x 10\^9/L. 4. Baseline liver and renal function is less than two times the normal value. 5. No active infection. 6. Agreed to sign the consent form. 7. Eastern Cooperative Oncology Group (ECOG) score of 0-2. Exclusion Criteria: 1. Other causes of whole blood cytopenia, such as myelodysplastic syndromes (MDS). 2. Presence of cytogenetic evidence of clonal haematological bone marrow disorders (MDS, AML). 3. PNH clones ≥50%. 4. Hematopoietic stem cell transplantation (HSCT) prior to enrolment. 5. Prior treatment with ATG. 6. Infection or bleeding uncontrolled by standard therapy. 7. Allergy to roprostin. 8. Active HIV, HCV or HBV infection or cirrhosis or portal hypertension. 9. Any concomitant malignancy, localised basal cell carcinoma of the skin within 5 years. 10. Previous history of thromboembolic events, heart attack or stroke (including antiphospholipid antibody syndrome) and current use of anticoagulants. 11. Pregnant or lactating (breastfeeding) women. 12. Participation in another clinical trial within 3 months.