Clinical Research Directory

Inclusion Criteria: 1. Participant is willing and able to give informed consent for participation in the trial. 2. In good general health as evidenced by medical history. 3. Presenting a single hopeless tooth candidate for extraction in the maxillary or mandibular area (from second premolar to second premolar, intercalated or the last tooth of dental arch) in need of a single implant-supported fixed prosthetic rehabilitation. 4. Presence of \>3mm of buccal wall dehiscence evaluated using Cone Beam Computed Tomography (CBCT). 5. In healthy periodontal conditions (i.e., no presence of sites ≥ 4 mm and/or presence of intra-bony defects in the selected sites, full mouth plaque score \< 20% and full-mouth bleeding score \< 20%). Exclusion Criteria: 1. Current or previous use of immunosuppressant, bisphosphonate, or high-dose corticosteroid therapy. 2. Presence of inflammatory and autoimmune disease of the oral cavity. 3. Severe or poorly controlled diabetes or previous radiotherapy of head area. 4. Contraindications to dental and/or surgical interventions (e.g. severe endocrine bone diseases, severe metabolic bone disorders, malignant tumour diseases). 5. Individuals who are smokers of \>10 cigarettes/day. 6. Female participant who is pregnant, lactating or planning pregnancy during the course of the study. 7. Presence of \<3mm of dehiscence of buccal walls of the socket after tooth extraction. 8. Presence of a distance between the interdental bone crest and buccal bone crest \<3 mm after tooth extraction.