Clinical Research Directory

Inclusion Criteria: 1. Diagnosed with SAA or vSAA 2. Aged 18-50 3. No severe organ injury 4. No uncontrolled active infections 5. Sign informed consent form, have the ability to comply with study and follow-up procedures Exclusion Criteria: 1. Hypersensitivity to NAC or history of bronchial asthma 2. Life expectancy less than 30 days post-transplantation 3. Uncontrolled infections pre-transplantation 4. Cardiac dysfunction (particularly congestive heart failure, unstable coronary artery disease and serious cardiac ventricular arrhythmias requiring antiarrhythmic therapy) 5. Respiratory failure ( PaO2 ≤60mmHg) 6. Hepatic abnormalities (total bilirubin ≥2 times the upper limit of normal \[ULN\], alanine aminotransferase or aspartate aminotransferase ≥2 times the ULN) 7. Renal dysfunction (creatinine ≥1.5 times the ULN or creatinine clearance rate \< 30 mL/min) 8. ECOG performance status ≥3 9. With any conditions not suitable for the trial (investigators' decision)