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A Novel Imaging Modality to Evaluate Radiation-Induced Uterine Injury
Sponsor: University of Colorado, Denver
Summary
The goal of this pilot study is to assess the ability of a new imaging modality, shear-wave-elastography (SWE) and magnetic resonance imaging (MRI) to identify radiation-induced uterine injury (RIUI). The investigator will recruit female patients treated before 40 years with pelvic radiation (PRT) at least 12 months prior to study initiation.
Key Details
Gender
FEMALE
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
22
Start Date
2025-02-25
Completion Date
2027-03
Last Updated
2025-09-23
Healthy Volunteers
No
Conditions
Interventions
MRI, SWE, and US evaluation
We will perform SWE and MRI sampling of the uterus from fundus to lower uterine segment with at least two points each from the upper, mid, and lower thirds of the uterus. SWE and MRI will be performed at time of study recruitment. US procedures will be transabdominal. When possible, we will also collect transvaginal US. MRI images will also be sampled from existing pretreatment studies performed as standard of care. All images will be evaluated for the presence and degree of fibrosis. We will compare SWE and MRI post-treatment. We will also compare pre-and post-treatment MRI. We will perform US and estimate uterine volumes and arterial resistance. Use descriptive statistics to compare values to age-matched controls
Locations (1)
University of Colorado
Aurora, Colorado, United States