Clinical Research Directory

Inclusion Criteria: * Age ≥ 18 * Male or, post-menopausal -with no menses for 12 months without an alternative medical cause- or permanently sterilized -hystercetomy, bilateral salpingectomy or bilateral oophorectomy- female * Successful transfemoral TAVI for symptomatic aortic stenosis as defined by VARC-33 * Successful access, delivery of the device, and retrieval of the delivery system * Correct positioning of a single prosthetic heart valve into the proper anatomical location * Freedom from surgery or intervention related to the device (excluding permanent pacemaker) or to a major vascular or access-related, or cardiac structural complication * Written informed consent * Social security affiliated * French speaking Exclusion Criteria: * Un-successful TAVI defined by the absence of any of the above-mentioned criteria defining successful TAVI3 * Alternative non-femoral-approach TAVI: apical, direct trans-aortic, subclavian, axillary or carotid approaches * TAVI for other indications than aortic stenosis (pure aortic regurgitation) * Valve in valve TAVI * Any indication for long term antiplatelet therapy: (e.g. coronary artery disease, cerebrovascular disease, peripheral arterial disease…) at any time prior to randomization * Any indication for oral anticoagulation: (e.g. atrial fibrillation, deep vein thrombosis, pulmonary embolism, ventricular thrombus…) at any time prior to randomization * Patients on long term antiplatelet or anticoagulant therapy prior to TAVI for any other indication than TAVI * Any contraindication to long term antiplatelet therapy (e.g. allergy or intolerance to aspirin, major bleeding, high bleeding risk, thrombocytopenia \< 50 000, major haemostasis disorder…) * Women of childbearing potential: non menopaused -with no menses for 12 months without an alternative medical cause- and not permanently sterilized -hystercetomy, bilateral salpingectomy or bilateral oophorectomy- * Adult with protective measures (tutorship, curatorship) * Patients considered as vulnerable by the investigators because of medical, psychological or social conditions: * Patients with known or discovered severe cognitive impairment * Patients with treated or untreated severe psychological or psychiatric conditions * Patients with uncorrected severe hearing or visual handicap * Patients with addictive alcohol, drug or substance abuse * Patients with protective measures (guardianship, tutorship, curatorship) * Any other condition considered by the investigators as not warranting informed consent