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RECRUITING
NCT06519526
PHASE2

Exploratory Clinical Study of SHR-0302 and SHR-2554 in Patients With Relapsed/Refractory Peripheral T Cell Lymphoma

Sponsor: Fudan University

View on ClinicalTrials.gov

Summary

This is an open-label, prospective and exploratory clinical study to evaluate the efficacy and safety of JAK inhibitor SHR-0302 in combination with EZH2 inhibitor SHR-2554 in patients with R/R PTCL. The study plans to enroll approximately 25 patients. 6-12 patients will receive SHR-0302 monotherapy and SHR-0302+SHR-2554 combination therapy in the safety run-in phase. According to the safety observed, the investigators discuss and decide to select a dose group to explore the efficacy and safety. 13 patients may be enrolled in the expansion phase.

Key Details

Gender

All

Age Range

18 Years - 70 Years

Study Type

INTERVENTIONAL

Enrollment

25

Start Date

2024-08-12

Completion Date

2027-08-31

Last Updated

2026-03-24

Healthy Volunteers

No

Interventions

DRUG

SHR-0302

SHR-0302 will be administered orally as tablets.

DRUG

SHR-2554

SHR-2554 will be administered orally as tablets.

Locations (1)

Fudan University Shanghai Cancer Center

Shanghai, China