Clinical Research Directory

Inclusion Criteria: 1. Aged ≥18 years; 2. Eastern Cooperative Oncology Group (ECOG) performance status score ≤2； 3. Endoscopic biopsies were pathologically confirmed as gastric adenocarcinoma； 4. The feasibility of neoadjuvant therapy was suggested by MDT, and the feasibility of radical gastrectomy was re-evaluated after neoadjuvant therapy; 5. Blood routine, liver function, kidney function, heart function and lung function were normal before neoadjuvant therapy, and there was no contraindication of chemotherapy and surgery; 6. The pregnancy test was negative within 1 month, and she was not pregnant or breastfeeding; 7. Informed consent and ability to comply with research protocols. Exclusion Criteria: 1. metastasis; 2. End-stage cardiac insufficiency (LVEF\<30% or NYHA class IV), liver cirrhosis (Child-Pugh classification C), End-stage renal failure (receives chronic dialysis), or ASA grade IV; 3. Cerebral hemorrhage, cerebral infarction, TIA or central nervous system disease or mental illness within 6 months, could not cooperate with the completion of neoadjuvant therapy and pre-rehabilitation exercise; 4. Patients have severe infections (such as MODS, etc.) or have allergic reactions to chemotherapy drugs and metabolic disorders; 5. Concurrent tumors or other diseases requiring simultaneous surgery (except laparoscopic gallbladder surgery); 6. Emergency surgery is required due to tumor complications (e.g., bleeding, perforation, obstruction); 7. Patients participating in other clinical trials.