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Effects of Minimal-Flow Sevoflurane and Multimodal Analgesia in Head and Neck Cancer Surgery
Sponsor: National Taiwan University Hospital
Summary
This study evaluates the anesthetic-sparing and renal protection effects of minimal-flow sevoflurane anesthesia combined with multimodal analgesia using dexmedetomidine, ketamine, and lidocaine in head and neck cancer patients undergoing free flap microvascular surgery. The 2x2 factorial randomized controlled trial aims to compare sevoflurane usage and renal function changes with different fresh gas flow rates and multimodal analgesia.
Official title: Anesthetic-sparing and Renal Protection Effects of Minimal-flow Sevoflurane Anesthesia and Multimodal Analgesia Using a Mixture of Dexmedetomidine-ketamine-lidocaine in Head and Neck Cancer Patients With Free Flap Microvascular Surgery
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2024-08
Completion Date
2025-12
Last Updated
2024-07-26
Healthy Volunteers
No
Interventions
Multimodal analgesia using dexmedetomidine-ketamine-lidocaine mixture
Multimodal analgesia using dexmedetomidine-ketamine-lidocaine mixture vs placebo normal saline
Minimal flow sevoflurane
Minimal flow sevoflurane anesthesia (0.5 L/min) vs low flow sevoflurane (1 L/min)