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Role of Citicoline in Treatment of Neonates With Hypoxic Ischemic Encephalopathy
Sponsor: Armed Forces Hospital, Pakistan
Summary
Hypoxic ischemic encephalopathy is an acute or subacute brain injury, due to asphyxia in neonates, leading to mortality and long-term morbidity. Its prevalence varies across regions, with developed countries reporting rates of 1.5 per 1000 live births, while developing nations experience a wider range from 2.3 to 26.5 per 1000 live births. Infants afflicted with moderate HIE face a 10% risk of mortality, with surviving individuals encountering a 30% chance of developing disabilities. The prognosis is graver for severe HIE, with a mortality risk of 60%, and nearly all survivors experiencing some form of disability.
Key Details
Gender
All
Age Range
1 Day - 30 Days
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2024-01-01
Completion Date
2025-01-01
Last Updated
2024-08-14
Healthy Volunteers
No
Interventions
Citicoline Sodium
one group of neonates with confirmed HIE grade II and III will receive injection citicoline through IV route within 06 hours of birth
Locations (1)
MH
Rawalpindi, Pakistan