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Statin Combined with Amlodipine Treats Primary Aldosteronism
Sponsor: Third Military Medical University
Summary
The drug treatment for primary aldosteronism (PA) is limited and difficult to improve long-term cardiovascular outcomes. This study plans to enroll patients with primary aldosteronism and randomly divide into 3 groups: scheme 1: Statin combined with amlodipine besylate, scheme 2: Statin combined with Spironolactone and Amlodipine besylate. scheme 3: Amlodipine besylate combined with Spironolactone , to observe the changes in plasma aldosterone level, 24-hour urinary aldosterone, blood pressure, and long-term cardiovascular risk.
Official title: A Prospective, Multi-center, Randomized Trial to Compare Statin Combined with CCB to MRA Combined with CCB in Primary Aldosteronism Treatment
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
180
Start Date
2024-09-10
Completion Date
2026-09-30
Last Updated
2024-11-22
Healthy Volunteers
No
Interventions
Simvastatin combined with Amlodipine besylate
6-month treatment of Simvastatin combined with Amlodipine besylate
Simvastatin combined with Spironolactone and Amlodipine besylate.
6-month treatment of Simvastatin combined with Spironolactone and Amlodipine besylate.
Amlodipine besylate combined Spironolactone
6-month treatment of Amlodipine besylate combined with Spironolactone
Locations (1)
No. 10 Changjiang River Branch, Yuzhong District，Chongqing, China
Chongqing, Chongqing Municipality, China