Clinical Research Directory

Inclusion Criteria: 1. Pathological diagnosis of osteosarcoma; 2. Age range 12-70 years old; 3. The primary or metastatic lesion cannot be surgically removed based on clinical evaluation, and treatment with internal medicine multi line chemotherapy, targeted therapy, immunotherapy, etc. is ineffective; 4. ECOG physical fitness status is 0-1 points; 5. According to RECIST version 1.1 standard, there must be at least one evaluable target lesion with a mass length diameter greater than 5cm; 6. Sign a written informed consent form before conducting any experimental activities; 7. Researchers determine that they are able to comply with the research protocol; 8. Patients who are willing and able to comply with visit arrangements, treatment plans, laboratory tests, and other research procedures. Exclusion Criteria: 1. Local mass previously received radiation therapy; 2. Major surgery ≤ 4 weeks before enrollment; 3. Previous or concurrent malignant tumors (excluding malignant tumors that have been cured and have a cancer free survival of more than 5 years, such as basal cell carcinoma of the skin and papillary thyroid carcinoma); 4. Pregnant or lactating women; 5. Active pulmonary tuberculosis.