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Relationship Between Different Administration Regimens of Ceftazidime/Avibactam and Clinical Outcomes
Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Summary
Ceftazidime/avibactam (CAZ/AVI) is a new β-lactam drug, which has good antibacterial effect against carbapenem resistant enterobacter. However, previous studies found that CAZ/AVI had a low PK/PD compliance rate after the recommended dose of the drug instructions.Therefore, this study was intended to explore the clinical efficacy of different administration schedules of CAZ/AVI for patients with severe infection, and further analyze the correlation between CAZ/AVI PK/PD parameters and clinical efficacy and adverse reactions.
Official title: Relationship Between Different Administration Regimens of Ceftazidime/Avibactam and Clinical Outcomes in Patients With Severe Infection: a Multicenter, Prospective, Randomized Controlled Study
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
140
Start Date
2024-07-01
Completion Date
2025-07-30
Last Updated
2024-07-30
Healthy Volunteers
No
Conditions
Interventions
CAZ/AVI
continuous infusion is used
CAZ/AVI
2h-infusion is used
Locations (1)
Intensive Care Unit, Drum Tower Hospital
Nanjing, Jiangsu, China