Clinical Research Directory

Inclusion Criteria: 1. Age between 30 and 65, for both males and females; 2. Inadequate exercise: Sedentary lifestyle: Sitting for more than 6 hours daily over the past 6 months; Insufficient physical activity evaluated by the International Physical Activity Questionnaire (IPAQ), with an average weekly duration of moderate-intensity physical activity less than 150 minutes or high-intensity physical activity less than 75 minutes; 3. Meeting the criteria for metabolic syndrome according to the 2009 AHA/IDF definition: Must have three or more of the following: Abdominal obesity(Waist circumference ≥90 cm for males, ≥80 cm for females); Elevated fasting blood glucose: ≥5.6 mmol/L; Elevated blood pressure: Systolic blood pressure ≥130 mm Hg, or diastolic blood pressure ≥85 mm Hg; Elevated fasting triglycerides (TG): ≥1.7 mmol/L (150 mg/dl); Reduced fasting high-density lipoprotein cholesterol (HDL-C): \<1.0 mmol/L for males, \<1.3 mmol/L for females. Additionally, must meet the following conditions: TG \<500 mg/dl (5.6 mmol/L); fasting blood glucose \<7 mmol/L; baseline blood pressure \<140/90 mm Hg; 4. Willingness to improve health status through reasonable exercise. Exclusion Criteria: 1. Contraindications to CPET (Cardiopulmonary Exercise Testing); 2. Positive results in CPET exercise electrocardiogram; 3. The patient has elevated LDL-C levels and has been indicated for statin therapy. 4. Currently undergoing treatment with antihypertensive, antidiabetic, lipid-lowering, or antiarrhythmic medications; 5. The doctor evaluates dietary supplements or over-the-counter medications that may affect the results (such as fish oil products, red yeast rice extract, over-the-counter weight loss drugs, meal replacements, probiotics, berberine, etc.) 6. Mental disorders; 7. Conditions related to exercise impairment, or occurrence of lower limb exercise-related injuries in the past 6 months; 8. Women who are pregnant, breastfeeding, or planning to become pregnant in the near future; 9. Other situations deemed unsuitable for participation in this study by the researchers; 10. Refusal to sign the informed consent form.