Clinical Research Directory

Inclusion Criteria: * Age ≥18 years * Diagnosis of liver cirrhosis, meeting at least one of the following criteria: * Clinical diagnosis: ICD-10-CM codes K74.100 and K74.607 from our hospital's electronic medical record system * Liver biopsy pathology or a combination of clinical, laboratory, and imaging examinations confirming liver cirrhosis: Pathological biopsy criteria: fibrosis bridging between lobules leading to lobular structural disarray, nodular regeneration of hepatocytes, formation of pseudo-lobules * Laboratory tests: the presence of at least 2 of the following 4 abnormal indicators suggesting liver cirrhosis: * a) Platelet count \< 100×10\^9/L, with no other explainable cause; * b) Serum albumin \< 35g/L, excluding malnutrition or kidney disease as other causes; * c) International normalized ratio (INR) \> 1.3 or prolonged prothrombin time (PT) (after discontinuation of thrombolytic or anticoagulant drugs for more than 7 days); * d)Aspartate aminotransferase to platelet ratio index (APRI) \> 2. * Availability of high-quality L3-level CT images Exclusion Criteria: * Incomplete sociodemographic, laboratory, or imaging data * Diagnosed or highly suspected malignancy * Severe chronic kidney disease, respiratory insufficiency, cardiovascular diseases, etc. * Neurological diseases and muscular degenerative diseases * Hyperthyroidism, hypothyroidism, tuberculosis, or any other diseases that may affect basal metabolism * Diseases or conditions causing malabsorption of intestinal nutrients, such as inflammatory bowel disease or gastrointestinal surgery * Treatment with glucocorticoids or immunosuppressants * Pregnancy or lactation