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Establishing Best Treatment Strategy for T4 Esophageal Cancer
Sponsor: National Cheng-Kung University Hospital
Summary
The goal of this clinical trial is to investigate the safety and efficacy of a new treatment approach for T4-stage esophageal cancer, which involves chemoradiotherapy after induction chemotherapy. The main questions it aims to answer are: * Does the new induction chemotherapy followed by chemoradiation reduce esophageal perforation rate? * Does the new induction chemotherapy followed by chemoradiation increase treatment response rate and patient survival? Researchers will analyze the above data to see if the new treatment approach works to treat T4 esophageal cancer. Participants will: * Receive induction chemotherapy for 4 to 8 cycles, followed by chemoradiation therapy if downstage to T3 * Visit the clinic once every week for checkups and tests * Keep a diary of their symptoms
Official title: A Pilot Study to Establish Best Treatment Strategy for T4 Esophageal Cancer
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
22
Start Date
2024-08-01
Completion Date
2026-04-30
Last Updated
2025-09-22
Healthy Volunteers
No
Interventions
"Docetaxel", "Cisplatin", "fluorouracil", "Radiation"
Induction chemotherapy with Docetaxel, Cisplatin, and fluorouracil for 4 to 8 cycles, followed by concurrent chemoradiotherapy with Cisplatin and Radiation 30.6-40 Gy.
Locations (1)
National Cheng Kung University Hospital
Tainan, Taiwan, Taiwan