Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
RECRUITING
NCT06531434
PHASE1/PHASE2

Establishing Best Treatment Strategy for T4 Esophageal Cancer

Sponsor: National Cheng-Kung University Hospital

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to investigate the safety and efficacy of a new treatment approach for T4-stage esophageal cancer, which involves chemoradiotherapy after induction chemotherapy. The main questions it aims to answer are: * Does the new induction chemotherapy followed by chemoradiation reduce esophageal perforation rate? * Does the new induction chemotherapy followed by chemoradiation increase treatment response rate and patient survival? Researchers will analyze the above data to see if the new treatment approach works to treat T4 esophageal cancer. Participants will: * Receive induction chemotherapy for 4 to 8 cycles, followed by chemoradiation therapy if downstage to T3 * Visit the clinic once every week for checkups and tests * Keep a diary of their symptoms

Official title: A Pilot Study to Establish Best Treatment Strategy for T4 Esophageal Cancer

Key Details

Gender

All

Age Range

18 Years - 70 Years

Study Type

INTERVENTIONAL

Enrollment

22

Start Date

2024-08-01

Completion Date

2026-04-30

Last Updated

2025-09-22

Healthy Volunteers

No

Interventions

COMBINATION_PRODUCT

"Docetaxel", "Cisplatin", "fluorouracil", "Radiation"

Induction chemotherapy with Docetaxel, Cisplatin, and fluorouracil for 4 to 8 cycles, followed by concurrent chemoradiotherapy with Cisplatin and Radiation 30.6-40 Gy.

Locations (1)

National Cheng Kung University Hospital

Tainan, Taiwan, Taiwan