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Electroencephalographic Characteristics of Chronic Pain in Patients With Spinal Cord Injury
Sponsor: Beijing Tiantan Hospital
Summary
The diagnosis of chronic pain currently lacks objective and quantifiable biomarkers. This study aims to observe the EEG characteristics of patients with chronic pain following spinal cord injury and subsequently administer analgesic interventions with remifentanil, esketamine, flurbiprofen, and spinal cord stimulation. The correlation between EEG features and pain intensity will be examined. The research aims to advance the objectification of chronic pain diagnosis and treatment.
Official title: Electroencephalographic Characteristics of Chronic Pain in Patients With Spinal Cord Injury: an Exploratory, Interventional, Non-randomized Controlled Study
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2024-08-25
Completion Date
2026-02-28
Last Updated
2024-08-13
Healthy Volunteers
No
Conditions
Interventions
Esketamine(Continuous infusion)
Continuous intravenous infusion of esketamine at a dose of 0.2 mg/(kg · h). Collect resting-state EEG data and NRS scores 40 minutes after administration.
Remifentanil (Target-Controlled Infusion)
The plasma drug concentrations of remifentanil were set at 0.5 ng/ml, 1 ng/ml, and 1.5 ng/ml. After each plasma drug concentration reached a steady state, the NRS scores were assessed, and resting-state EEG was recorded for at least 5 minutes.
Flurbiprofen (Single intravenous injection)
Single intravenous injection of Flurbiprofen at a dose of 100 mg. Collect resting-state EEG data and NRS scores 10 minutes after administration.
Spinal Cord Stimulation
Collect resting-state EEG data and NRS scores with the spinal cord stimulator both turned off and on.
No intervention
Collect resting-state EEG data and NRS scores.
Locations (1)
Beijing Tiantan Hospital
Beijing, China